Recent Neel Lab Publications

2024

• A Mechanism for Hypoxia Induced Inflammatory Cell Death in Cancer.
  Bhardwaj A, Panepinto MC, Ueberheide B, Neel BG.
  Nature. (Accepted), bioRxiv2023.08.05.552118; doi: https://doi.org/10.1101/2023.08.05.552118. Free PMC article. Preprint.
• Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes.
  Maso L, Rajak E, Bang I, Koide A, Hattori T, Neel BG, Koide S.
  Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2319029121. doi: 10.1073/pnas.2319029121. Epub 2024 May 23. PMID: 38781214 Free PMC article.
• Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation.
  Tsutsumi R, Ueberheide B, Liang FX, Neel BG, Sakai R, Saito Y.
  Nat Commun. 2024 Apr 2;15(1):2843. doi: 10.1038/s41467-024-46971-9.
  PMID: 38565573 Free PMC article.
• Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.
  Tong X, Patel AS, Kim E, Li H, Chen Y, Li S, Liu S, Dilly J, Kapner KS, Zhang N, Xue Y, Hover L, Mukhopadhyay S, Sherman F, Myndzar K, Sahu P, Gao Y, Li F, Li F, Fang Z, Jin Y, Gao J, Shi M, Sinha S, Chen L, Chen Y, Kheoh T, Yang W, Yanai I, Moreira AL, Velcheti V, Neel BG, Hu L, Christensen JG, Olson P, Gao D, Zhang MQ, Aguirre AJ, Wong KK, Ji H.
  Cancer Cell. 2024 Mar 11;42(3):413-428.e7. doi: 10.1016/j.ccell.2024.01.012. Epub 2024 Feb 22.PMID: 38402609.

2023

• Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
  Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG.
  Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729.
  PMID: 37729426 Free PMC article.
• Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.
  Sun R, Ge W, Zhu Y, Sayad A, Luna A, Lyu M, Liang S, Tobalina L, Rajapakse VN, Yu C, Zhang H, Fang J, Wu F, Xie H, Saez-Rodriguez J, Ying H, Reinhold WC, Sander C, Pommier Y, Neel BG, Aebersold R, Guo T.
  Mol Cell Proteomics. 2023 Aug;22(8):100602. doi: 10.1016/j.mcpro.2023.100602. Epub 2023 Jun 19.
  PMID: 37343696 Free PMC article.
• In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer.
  Deng J, Peng DH, Fenyo D, Yuan H, Lopez A, Levin DS, Meynardie M, Quinteros M, Ranieri M, Sahu S, Lau SCM, Shum E, Velcheti V, Punekar SR, Rekhtman N, Dowling CM, Weerasekara V, Xue Y, Ji H, Siu Y, Jones D, Hata AN, Shimamura T, Poirier JT, Rudin CM, Hattori T, Koide S, Papagiannakopoulos T, Neel BG, Bardeesy N, Wong KK.
  bioRxiv [Preprint]. 2023 Apr 20:2023.04.18.537350. doi: 10.1101/2023.04.18.537350.
  PMID: 37131623 Free PMC article. Preprint.
• Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition
  Wei Wei , Mitchell J. Geer, Xinyi Guo, Igor Dolgalev, Neville E. Sanjana, and Benjamin G. Neel
  J Exp Med (2023) 220 (5): e20221563. doi: 10.1084/jem.20221563 Epub 2023 Feb 23.

2021

• Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
  Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R Brown, Allison M.L Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-Kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran and Benjamin G Neel
  Cancer Discov. OnlineFirst version published on December 15, 2021. doi: 10.1158/2159-8290.CD-20-1265
• Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC.
  Tang KH, Li S, Khodadadi-Jamayran A, Jen J, Han H, Guidry K, Chen T, Hao Y, Fedele C, Zebala JA, Maeda DY, Christensen JG, Olson P, Athanas A, Loomis CA, Tsirigos A, Wong KK, Neel BG.
  Cancer Discov. 2021 Aug 5:candisc.0369.2021. doi: 10.1158/2159-8290.CD-21-0369. Online ahead of print.
  PMID: 34353854
• Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.
  Shengqing Gu, Stephanie Lheureux, Azin Sayada, Paulina Cybulska, Liat Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy R. Parulekar, Matthew Nankivell, Sean Kehoe, Dennis S. Chi, Douglas A. Levine, Marcus Q. Bernardini, Barry Rosen, Amit Oza, Myles Brown, and Benjamin G. Neel
  PNAS June 22, 2021 118 (25) e2026663118; https://doi.org/10.1073/pnas.2026663118 [Contributed by Myles Brown, May 7, 2021]
• Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer
  Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, Levine DA, Weinberg RA, Neel BG.
  Cancer Discov. 2021 Feb;11(2):362-383. doi: 10.1158/2159-8290.CD-20-0455. Epub 2020 Nov 6.
  PMID: 33158842
• Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy.
  Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Pérez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pépin D, Weinberg RA.
  Cancer Discov. 2021 Feb;11(2):384-407. doi: 10.1158/2159-8290.CD-20-0818. Epub 2020 Nov 6.
  PMID: 33158843
• SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling
  Carmine Fedele, Shuai Li, Kai Wen Teng, Connor Foster, David Peng, Hao Ran, Paolo Mita, Mitchell Geer, Takamitsu Hattori, Akiko Koide, Yubao Wang, Kwan H. Tang, Joshua Leinwand, Wei Wang, Brian Diskin, Jiehui Deng, Ting Chen, Igor Dolgalev, Ugur Ozerdem, George Miller, Shohei Koide, Kwok-Kin Wong, Benjamin G. Neel
  J Exp Med (2021) 218 (1): e20201414.
  https://doi.org/10.1084/jem.20201414 [preprint posted on bioRxiv 2020 May 31]

2020

• Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21.
  Hussain A, Voisin V, Poon S, Karamboulas C, Bui NHB, Meens J, Dmytryshyn J, Ho VW, Tang KH, Paterson J, Clarke BA, Bernardini MQ, Bader GD, Neel BG, Ailles LE.
  J Exp Med. 2020 Aug 3;217(8):e20191094. doi: 10.1084/jem.20191094.
  PMID: 32434219
• Moyamoya Disease-Associated RNF213 Alleles Encode Dominant Negative Alleles That Globally Impair Ubiquitylation
  Abhishek Bhardwaj, Robert S. Banh, Wei Zhang, Sachdev S. Sidhu, Benjamin G. Neel
  doi: https://doi.org/10.1101/2020.05.24.113795 [preprint posted on bioRxiv 2020 May 26]