All Publications (1981-present)

2024

• A Mechanism for Hypoxia Induced Inflammatory Cell Death in Cancer.
  Bhardwaj A, Panepinto MC, Ueberheide B, Neel BG.
  Nature. (Accepted), bioRxiv2023.08.05.552118; doi: https://doi.org/10.1101/2023.08.05.552118. Free PMC article. Preprint.
• Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes.
  Maso L, Rajak E, Bang I, Koide A, Hattori T, Neel BG, Koide S.
  Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2319029121. doi: 10.1073/pnas.2319029121. Epub 2024 May 23. PMID: 38781214 Free PMC article.
• Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation.
  Tsutsumi R, Ueberheide B, Liang FX, Neel BG, Sakai R, Saito Y.
  Nat Commun. 2024 Apr 2;15(1):2843. doi: 10.1038/s41467-024-46971-9.
  PMID: 38565573 Free PMC article.
• Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.
  Tong X, Patel AS, Kim E, Li H, Chen Y, Li S, Liu S, Dilly J, Kapner KS, Zhang N, Xue Y, Hover L, Mukhopadhyay S, Sherman F, Myndzar K, Sahu P, Gao Y, Li F, Li F, Fang Z, Jin Y, Gao J, Shi M, Sinha S, Chen L, Chen Y, Kheoh T, Yang W, Yanai I, Moreira AL, Velcheti V, Neel BG, Hu L, Christensen JG, Olson P, Gao D, Zhang MQ, Aguirre AJ, Wong KK, Ji H.
  Cancer Cell. 2024 Mar 11;42(3):413-428.e7. doi: 10.1016/j.ccell.2024.01.012. Epub 2024 Feb 22.PMID: 38402609.

2023

• Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
  Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG.
  Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729.
  PMID: 37729426 Free PMC article.
• Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.
  Sun R, Ge W, Zhu Y, Sayad A, Luna A, Lyu M, Liang S, Tobalina L, Rajapakse VN, Yu C, Zhang H, Fang J, Wu F, Xie H, Saez-Rodriguez J, Ying H, Reinhold WC, Sander C, Pommier Y, Neel BG, Aebersold R, Guo T.
  Mol Cell Proteomics. 2023 Aug;22(8):100602. doi: 10.1016/j.mcpro.2023.100602. Epub 2023 Jun 19.
  PMID: 37343696 Free PMC article.
• In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer.
  Deng J, Peng DH, Fenyo D, Yuan H, Lopez A, Levin DS, Meynardie M, Quinteros M, Ranieri M, Sahu S, Lau SCM, Shum E, Velcheti V, Punekar SR, Rekhtman N, Dowling CM, Weerasekara V, Xue Y, Ji H, Siu Y, Jones D, Hata AN, Shimamura T, Poirier JT, Rudin CM, Hattori T, Koide S, Papagiannakopoulos T, Neel BG, Bardeesy N, Wong KK.
  bioRxiv [Preprint]. 2023 Apr 20:2023.04.18.537350. doi: 10.1101/2023.04.18.537350.
  PMID: 37131623 Free PMC article. Preprint.
• Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition
  Wei Wei , Mitchell J. Geer, Xinyi Guo, Igor Dolgalev, Neville E. Sanjana, and Benjamin G. Neel
  J Exp Med (2023) 220 (5): e20221563. doi: 10.1084/jem.20221563 Epub 2023 Feb 23.

2021

• Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
  Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R Brown, Allison M.L Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-Kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran and Benjamin G Neel
  Cancer Discov. OnlineFirst version published on December 15, 2021. doi: 10.1158/2159-8290.CD-20-1265
• Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC.
  Tang KH, Li S, Khodadadi-Jamayran A, Jen J, Han H, Guidry K, Chen T, Hao Y, Fedele C, Zebala JA, Maeda DY, Christensen JG, Olson P, Athanas A, Loomis CA, Tsirigos A, Wong KK, Neel BG.
  Cancer Discov. 2021 Aug 5:candisc.0369.2021. doi: 10.1158/2159-8290.CD-21-0369. Online ahead of print.
  PMID: 34353854
• Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.
  Shengqing Gu, Stephanie Lheureux, Azin Sayada, Paulina Cybulska, Liat Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy R. Parulekar, Matthew Nankivell, Sean Kehoe, Dennis S. Chi, Douglas A. Levine, Marcus Q. Bernardini, Barry Rosen, Amit Oza, Myles Brown, and Benjamin G. Neel
  PNAS June 22, 2021 118 (25) e2026663118; https://doi.org/10.1073/pnas.2026663118 [Contributed by Myles Brown, May 7, 2021]
• Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer
  Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, Levine DA, Weinberg RA, Neel BG.
  Cancer Discov. 2021 Feb;11(2):362-383. doi: 10.1158/2159-8290.CD-20-0455. Epub 2020 Nov 6.
  PMID: 33158842
• Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy.
  Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Pérez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pépin D, Weinberg RA.
  Cancer Discov. 2021 Feb;11(2):384-407. doi: 10.1158/2159-8290.CD-20-0818. Epub 2020 Nov 6.
  PMID: 33158843
• SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling
  Carmine Fedele, Shuai Li, Kai Wen Teng, Connor Foster, David Peng, Hao Ran, Paolo Mita, Mitchell Geer, Takamitsu Hattori, Akiko Koide, Yubao Wang, Kwan H. Tang, Joshua Leinwand, Wei Wang, Brian Diskin, Jiehui Deng, Ting Chen, Igor Dolgalev, Ugur Ozerdem, George Miller, Shohei Koide, Kwok-Kin Wong, Benjamin G. Neel
  J Exp Med (2021) 218 (1): e20201414.
  https://doi.org/10.1084/jem.20201414 [preprint posted on bioRxiv 2020 May 31]

2020

• Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21.
  Hussain A, Voisin V, Poon S, Karamboulas C, Bui NHB, Meens J, Dmytryshyn J, Ho VW, Tang KH, Paterson J, Clarke BA, Bernardini MQ, Bader GD, Neel BG, Ailles LE.
  J Exp Med. 2020 Aug 3;217(8):e20191094. doi: 10.1084/jem.20191094.
  PMID: 32434219
• Moyamoya Disease-Associated RNF213 Alleles Encode Dominant Negative Alleles That Globally Impair Ubiquitylation
  Abhishek Bhardwaj, Robert S. Banh, Wei Zhang, Sachdev S. Sidhu, Benjamin G. Neel
  doi: https://doi.org/10.1101/2020.05.24.113795 [preprint posted on bioRxiv 2020 May 26]

2019

• Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.
  Shuang Zhang, Igor Dolgalev, Tao Zhang, Hao Ran, Douglas A. Levine, Benjamin G. Neel
  Nat Commun 10, 5367 (2019) doi:10.1038/s41467-019-13116-2 [preprint posted on bioRxiv 2018 Nov 29]
• The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.
  Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA.
  Blood. 2019 Jan 24;133(4):331-343. doi: 10.1182/blood-2018-09-877787. Epub 2018 Nov 14. PMID: 30429161
• Computational Modeling of Ovarian Cancer Reveals Optimal Strategies for Therapy and Screening
  Shengqing S Gu, Stephanie Lheureux, Azin Sayad, Paulina Cybulska, Liat Ben-David Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy Parulekar, Douglas A Levine, Marcus Q Bernardini, Barry Rosen, Amit Oza, Benjamin G Neel
  doi: https://doi.org/10.1101/19009712 [preprint posted on MedRxiv 2019 Oct 18]
• N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.
  Sinha A, Hussain A, Ignatchenko V, Ignatchenko A, Tang KH, Ho VWH, Neel BG, Clarke B, Bernardini MQ, Ailles L, Kislinger T.
  Cell Syst. 2019 Apr 24;8(4):345-351.e4. doi: 10.1016/j.cels.2019.03.011. Epub 2019 Apr 10. PMID: 30981729
• An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
  Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H.
  Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22.
  PMID: 31011202
• The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.
  Holter MC, Hewitt LT, Koebele SV, Judd JM, Xing L, Bimonte-Nelson HA, Conrad CD, Araki T, Neel BG, Snider WD, Newbern JM.
  PLoS Genet. 2019 Apr 24;15(4):e1008108. doi: 10.1371/journal.pgen.1008108. eCollection 2019 Apr. PMID: 31017896
• Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.
  Jiang DM, Fyles A, Nguyen LT, Neel BG, Sacher A, Rottapel R, Wang BX, Ohashi PS, Sridhar SS.
  Oncotarget. 2019 Apr 26;10(31):2947-2958. doi: 10.18632/oncotarget.26893. eCollection 2019 Apr 26.
  PMID: 31105877
• Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival.
  Nair NU, Das A, Rogkoti VM, Fokkelman M, Marcotte R, de Jong CG, Koedoot E, Lee JS, Meilijson I, Hannenhalli S, Neel BG, de Water BV, Le Dévédec SE, Ruppin E.
  Sci Rep. 2019 Jul 29;9(1):10989. doi: 10.1038/s41598-019-47440-w.
  PMID: 31358840
• Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation.
  Xu Y, Andrade J, Ueberheide B, Neel BG.
  FASEB J. 2019 Nov;33(11):12336-12347. doi: 10.1096/fj.201900693R. Epub 2019 Aug 26. PMID: 31451050
• Catalytic dysregulation of SHP2 leading to Noonan syndromes impacts on platelet signaling and functions.
  Bellio M, Garcia C, Edouard T, Voisin S, Neel BG, Cabou C, Valet P, Mori J, Mazharian A, Senis YA, Yart A, Payrastre B, Severin S.
  Blood. 2019 Sep 27. pii: blood.2019001543. doi: 10.1182/blood.2019001543. [Epub ahead of print] PMID: 31562133

2018

• Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma
  Benjamin G Neel, Shuang Zhang, Tao Zhang, Igor Dolgalev, Hao Ran, Douglas A Levine
  bioRxiv 481200; doi: https://doi.org/10.1101/481200 [preprint posted on bioRxiv]
• The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.
  Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA.
  Blood. 2018 Nov 14. pii: blood-2018-09-877787. doi: 10.1182/blood-2018-09-877787. [Epub ahead of print]

  PMID: 30429161

• Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.
  Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM, Neel BG.
  Cancer Res. 2018 Oct 8. pii: canres.0901.2018. doi: 10.1158/0008-5472.CAN-18-0901. [Epub ahead of print]

  PMID: 30297534

• Off-target inhibition by active site-targeting SHP2 inhibitors.
  Tsutsumi R, Ran H, Neel BG.
  FEBS Open Bio. 2018 Aug 1;8(9):1405-1411. doi: 10.1002/2211-5463.12493. eCollection 2018 Sep.

  PMID: 30186742 Free PMC Article

• SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.
  Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH.
  Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25.

  PMID: 30045908

• Vitamin C in Stem Cell Reprogramming and Cancer.
  Cimmino L, Neel BG, Aifantis I.
  Trends Cell Biol. 2018 Sep;28(9):698-708. doi: 10.1016/j.tcb.2018.04.001. Epub 2018 Apr 30. Review.

  PMID: 29724526

• Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.
  Tajan M, Pernin-Grandjean J, Beton N, Gennero I, Capilla F, Neel BG, Araki T, Valet P, Tauber M, Salles JP, Yart A, Edouard T.
  Hum Mol Genet. 2018 Jul 1;27(13):2276-2289. doi: 10.1093/hmg/ddy133.

  PMID: 29659837

• SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.
  Zuo C, Wang L, Kamalesh RM, Bowen ME, Moore DC, Dooner MS, Reginato AM, Wu Q, Schorl C, Song Y, Warman ML, Neel BG, Ehrlich MG, Yang W.
  Bone Res. 2018 Apr 6;6:12. doi: 10.1038/s41413-018-0013-z. eCollection 2018.

  PMID: 29644115 Free PMC Article

• Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
  Zheng H, Yu WM, Waclaw RR, Kontaridis MI, Neel BG, Qu CK.
  Sci Signal. 2018 Mar 20;11(522). pii: eaao1591. doi: 10.1126/scisignal.aao1591.

  PMID: 29559584 Free PMC Article

• A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing.
  Cybulska P, Stewart JM, Sayad A, Virtanen C, Shaw PA, Clarke B, Stickle N, Bernardini MQ, Neel BG.
  Am J Pathol. 2018 May;188(5):1120-1131. doi: 10.1016/j.ajpath.2018.01.019. Epub 2018 Feb 16.

  PMID: 29458007

• Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.
  Peled M, Tocheva AS, Sandigursky S, Nayak S, Philips EA, Nichols KE, Strazza M, Azoulay-Alfaguter I, Askenazi M, Neel BG, Pelzek AJ, Ueberheide B, Mor A.
  Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E468-E477. doi: 10.1073/pnas.1710437115. Epub 2017 Dec 27.

  PMID: 29282323 Free PMC Article

• Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts.
  Brana I, Pham NA, Kim L, Sakashita S, Li M, Ng C, Wang Y, Loparco P, Sierra R, Wang L, Clarke BA, Neel BG, Siu LL, Tsao MS.
  Oncotarget. 2017 Jul 8;8(49):84659-84670. doi: 10.18632/oncotarget.19109. eCollection 2017 Oct 17.

  PMID: 29156674 Free PMC Article

• Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.
  Le Sommer S, Morrice N, Pesaresi M, Thompson D, Vickers MA, Murray GI, Mody N, Neel BG, Bence KK, Wilson HM, Delibegović M.
  Cancer Res. 2018 Jan 1;78(1):75-87. doi: 10.1158/0008-5472.CAN-17-0946. Epub 2017 Nov 9.

  PMID: 29122767 Free PMC Article

• A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
  Wang L, Iorio C, Yan K, Yang H, Takeshita S, Kang S, Neel BG, Yang W.
  FASEB J. 2018 Feb;32(2):875-887. doi: 10.1096/fj.201700672RR. Epub 2018 Jan 4.

  PMID: 29046360

• Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.
  Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG.
  Nat Commun. 2017 Sep 6;8(1):466. doi: 10.1038/s41467-017-00503-w.

  PMID: 28878211 Free PMC Article

• Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
  Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I.
  Cell. 2017 Sep 7;170(6):1079-1095.e20. doi: 10.1016/j.cell.2017.07.032. Epub 2017 Aug 17.

  PMID: 28823558 Free PMC Article

• SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
  Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, Van Etten RA, Neel BG.
  Leukemia. 2018 Jan;32(1):203-213. doi: 10.1038/leu.2017.250. Epub 2017 Aug 14.

  PMID: 28804122 Free PMC Article

Earlier papers

• Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.
  Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG.
  Nat Commun. 2017 May 26;8:15518. doi: 10.1038/ncomms15518.

  PMID: 28548091 Free PMC Article

• Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.
  Zhang X, Dong Z, Zhang C, Ung CY, He S, Tao T, Oliveira AM, Meves A, Ji B, Look AT, Li H, Neel BG, Zhu S.
  Cell Rep. 2017 Mar 21;18(12):2932-2942. doi: 10.1016/j.celrep.2017.02.065.

  PMID: 28329685 Free PMC Article

• Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.
  Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R.
  Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028.

  PMID: 28273451 Free Article

• Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.
  Tong J, Helmy M, Cavalli FM, Jin L, St-Germain J, Karisch R, Taylor P, Minden MD, Taylor MD, Neel BG, Bader GD, Moran MF.
  Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600361.

  PMID: 28176486 Free PMC Article

• A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
  Yao Z, Darowski K, St-Denis N, Wong V, Offensperger F, Villedieu A, Amin S, Malty R, Aoki H, Guo H, Xu Y, Iorio C, Kotlyar M, Emili A, Jurisica I, Neel BG, Babu M, Gingras AC, Stagljar I.
  Mol Cell. 2017 Jan 19;65(2):347-360. doi: 10.1016/j.molcel.2016.12.004. Epub 2017 Jan 5.

  PMID: 28065597 Free PMC Article

• Cancer: Bad neighbours cause bad blood.
  Chan G, Neel BG.
  Nature. 2016 Nov 10;539(7628):173-175. doi: 10.1038/nature19479. Epub 2016 Oct 26. No abstract available.

  PMID: 27783594 Free PMC Article

• Sticking It to Cancer with Molecular Glue for SHP2.
  Ran H, Tsutsumi R, Araki T, Neel BG.
  Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010.

  PMID: 27505669 Free PMC Article

• PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
  Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
  Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20.

  PMID: 27323329 Free PMC Article

• Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).
  Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M.
  J Biol Chem. 2016 Jul 22;291(30):15641-52. doi: 10.1074/jbc.M116.714196. Epub 2016 May 18.

  PMID: 27226556 Free PMC Article

• Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.
  Gu S, Chan WW, Mohi G, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA.
  Blood. 2016 Apr 7;127(14):1803-13. doi: 10.1182/blood-2015-06-653006. Epub 2016 Jan 15.

  PMID: 26773044 Free PMC Article

• Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
  Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe’er D, Moffat J, Neel BG.
  Cell. 2016 Jan 14;164(1-2):293-309. doi: 10.1016/j.cell.2015.11.062.

  PMID: 26771497 Free PMC Article

• Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
  Liu X, Zheng H, Li X, Wang S, Meyerson HJ, Yang W, Neel BG, Qu CK.
  Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):984-9. doi: 10.1073/pnas.1508535113. Epub 2016 Jan 11.

  PMID: 26755576 Free PMC Article

• Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
  Hatlen MA, Arora K, Vacic V, Grabowska EA, Liao W, Riley-Gillis B, Oschwald DM, Wang L, Joergens JE, Shih AH, Rapaport F, Gu S, Voza F, Asai T, Neel BG, Kharas MG, Gonen M, Levine RL, Nimer SD.
  J Exp Med. 2016 Jan 11;213(1):25-34. doi: 10.1084/jem.20150524. Epub 2015 Dec 14.

  PMID: 26666262 Free PMC Article

• The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
  Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF.
  Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2.

  PMID: 26331541 Free PMC Article

• Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
  Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, Quevedo R, Hamid A, Martinelli S, Pantaleoni F, Gnazzo M, Daniele P, Lissewski C, Bocchinfuso G, Stella L, Odent S, Philip N, Faivre L, Vlckova M, Seemanova E, Digilio C, Zenker M, Zampino G, Verloes A, Dallapiccola B, Roberts AE, Cavé H, Gelb BD, Neel BG, Tartaglia M.
  Hum Mutat. 2015 Nov;36(11):1080-7. doi: 10.1002/humu.22834. Epub 2015 Aug 3.

  PMID: 26173643 Free PMC Article

• Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.
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• Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
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• Leptin and insulin act on POMC neurons to promote the browning of white fat.
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• Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
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• Differential regulation of FGFR3 by PTPN1 and PTPN2.
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• Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.
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• New pROSpects for PTP1B: micro-managing oncogene-induced senescence.
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• Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.
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• Next-generation sequencing identifies rare variants associated with Noonan syndrome.
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• Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
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• Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).
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  BMC Struct Biol. 2014 Mar 14;14:10. doi: 10.1186/1472-6807-14-10.

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• PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
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  Blood. 2014 May 1;123(18):2838-42. doi: 10.1182/blood-2013-10-535104. Epub 2014 Feb 19.

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• The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.
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  Cancer Cell. 2014 Feb 10;25(2):181-95. doi: 10.1016/j.ccr.2014.01.025.

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• Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.
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• Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.
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  Hepatology. 2014 May;59(5):1803-15. doi: 10.1002/hep.26957. Epub 2014 Apr 1.

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• Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
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  Breast Cancer Res. 2013;15(4):R65.

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• Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
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  Science. 2013 Jul 26;341(6144):395-9. doi: 10.1126/science.1236188. Erratum in: Science. 2013 Sep 6;341(6150):1064.

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• Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
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  Nature. 2013 Jul 25;499(7459):491-5. doi: 10.1038/nature12396. Epub 2013 Jul 17.

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• Shp1 regulates T cell homeostasis by limiting IL-4 signals.
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• Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.
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  Nat Commun. 2013;4:2037. doi: 10.1038/ncomms3037.

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• Biologically-targeted detection of primary and micro-metastatic ovarian cancer.
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  Theranostics. 2013 May 25;3(6):420-7. doi: 10.7150/thno.6413. Print 2013.

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• Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.
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  EMBO Mol Med. 2013 Jun;5(6):904-18. doi: 10.1002/emmm.201201429. Epub 2013 May 24.

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• Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.
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  Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.

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• Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.
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• Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.
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  Blood. 2013 May 16;121(20):4205-20. doi: 10.1182/blood-2012-08-449272. Epub 2013 Mar 18.

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• NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
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• Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.
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• From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis.
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• Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.
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  Cell Rep. 2012 Oct 25;2(4):951-63. doi: 10.1016/j.celrep.2012.09.016. Epub 2012 Oct 19.

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• Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.
  Mori J, Wang YJ, Ellison S, Heising S, Neel BG, Tremblay ML, Watson SP, Senis YA.
  Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2956-65. doi: 10.1161/ATVBAHA.112.300447. Epub 2012 Oct 11.

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• Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
  Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD.
  J Cell Sci. 2012 Nov 15;125(Pt 22):5535-45. doi: 10.1242/jcs.111260. Epub 2012 Sep 12.

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• Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial.
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• The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
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• Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.
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• Tyrosyl phosphorylation toggles a Runx1 switch.
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• Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.
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  Diabetes. 2012 Aug;61(8):1949-58. doi: 10.2337/db11-1502. Epub 2012 Jun 14.

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• Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
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  PLoS One. 2012;7(5):e36633. doi: 10.1371/journal.pone.0036633. Epub 2012 May 24.

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• Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
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• Methods to monitor classical protein-tyrosine phosphatase oxidation.
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• Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
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  PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28.

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• Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
  De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A.
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• Cancer genomics: technology, discovery, and translation.
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  J Clin Oncol. 2012 Feb 20;30(6):647-60. doi: 10.1200/JCO.2011.39.2316. Epub 2012 Jan 23. Review. Erratum in: J Clin Oncol. 2012 Apr 1;30(10):1149.

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• T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice.
  Loh K, Merry TL, Galic S, Wu BJ, Watt MJ, Zhang S, Zhang ZY, Neel BG, Tiganis T.
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• Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.
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• Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
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  Cell Metab. 2011 Nov 2;14(5):684-99. doi: 10.1016/j.cmet.2011.09.011. Epub 2011 Oct 13. Erratum in: Cell Metab. 2012 Jun 6;15(6):925-6.

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• TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
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• Global proteomic assessment of the classical protein-tyrosine phosphatome and “Redoxome”.
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• Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.
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• SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.
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• G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
  Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ.
  Blood. 2011 Jul 28;118(4):1077-86. doi: 10.1182/blood-2009-12-261636. Epub 2011 Jun 2.

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• Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.
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• Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
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  Blood. 2011 Apr 21;117(16):4253-61. doi: 10.1182/blood-2010-11-319517. Epub 2011 Feb 25.

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• Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
  Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, Wu X, Lauriol J, Wang B, Bauer M, Bronson R, Franchini KG, Neel BG, Kontaridis MI.
  J Clin Invest. 2011 Mar;121(3):1026-43. doi: 10.1172/JCI44972. Epub 2011 Feb 21.

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• MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
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• Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.
  Ren L, Chen X, Luechapanichkul R, Selner NG, Meyer TM, Wavreille AS, Chan R, Iorio C, Zhou X, Neel BG, Pei D.
  Biochemistry. 2011 Mar 29;50(12):2339-56. doi: 10.1021/bi1014453. Epub 2011 Feb 18.

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• Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
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  Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.

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• PTP1B regulates Eph receptor function and trafficking.
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• Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2.
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  J Biol Chem. 2010 Dec 17;285(51):39750-8. doi: 10.1074/jbc.M110.153734. Epub 2010 Sep 14.

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• Tumor-initiating cells are rare in many human tumors.
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  Cell Stem Cell. 2010 Sep 3;7(3):279-82. doi: 10.1016/j.stem.2010.08.009.

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• Regulation of kidney development by Shp2: an unbiased stereological analysis.
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  Anat Rec (Hoboken). 2010 Dec;293(12):2147-53. doi: 10.1002/ar.21236. Epub 2010 Aug 23.

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• A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
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• Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
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  Dev Cell. 2010 May 18;18(5):750-62. doi: 10.1016/j.devcel.2010.03.009.

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• Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.
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• Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.
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• Real-time NMR study of three small GTPases reveals that fluorescent 2′(3′)-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.
  Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M.
  J Biol Chem. 2010 Feb 19;285(8):5132-6. doi: 10.1074/jbc.C109.064766. Epub 2009 Dec 14.

  PMID: 20018863 Free PMC Article

• Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.
  Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T.
  Am J Med Genet A. 2010 Jan;152A(1):4-24. doi: 10.1002/ajmg.a.33183.

  PMID: 20014119 Free PMC Article

• A suggested role for mitochondria in Noonan syndrome.
  Lee I, Pecinova A, Pecina P, Neel BG, Araki T, Kucherlapati R, Roberts AE, Hüttemann M.
  Biochim Biophys Acta. 2010 Feb;1802(2):275-83. doi: 10.1016/j.bbadis.2009.10.005. Epub 2009 Oct 14.

  PMID: 19835954 Free PMC Article

• Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
  Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB.
  Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15.

  PMID: 19528236 Free PMC Article

• Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.
  Araki T, Chan G, Newbigging S, Morikawa L, Bronson RT, Neel BG.
  Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41. doi: 10.1073/pnas.0810053106. Epub 2009 Feb 27.

  PMID: 19251646 Free PMC Article

• Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
  Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG.
  Blood. 2009 Apr 30;113(18):4414-24. doi: 10.1182/blood-2008-10-182626. Epub 2009 Jan 29.

  PMID: 19179468 Free PMC Article

• Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
  Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.
  Diabetes. 2009 Mar;58(3):590-9. doi: 10.2337/db08-0913. Epub 2008 Dec 15.

  PMID: 19074988 Free PMC Article

• The Skap-hom dimerization and PH domains comprise a 3′-phosphoinositide-gated molecular switch.
  Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ.
  Mol Cell. 2008 Nov 21;32(4):564-75. doi: 10.1016/j.molcel.2008.09.022.

  PMID: 19026786 Free PMC Article

• Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
  Kalaitzidis D, Neel BG.
  PLoS One. 2008;3(11):e3776. doi: 10.1371/journal.pone.0003776. Epub 2008 Nov 20.

  PMID: 19020663 Free PMC Article

• Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
  Wang S, Yu WM, Zhang W, McCrae KR, Neel BG, Qu CK.
  J Biol Chem. 2009 Jan 9;284(2):913-20. doi: 10.1074/jbc.M804129200. Epub 2008 Nov 13.

  PMID: 19008228 Free PMC Article

• Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells.
  Zucchi I, Astigiano S, Bertalot G, Sanzone S, Cocola C, Pelucchi P, Bertoli G, Stehling M, Barbieri O, Albertini A, Schöler HR, Neel BG, Reinbold RA, Dulbecco R.
  Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16940-5. doi: 10.1073/pnas.0808978105. Epub 2008 Oct 28.

  PMID: 18957543 Free PMC Article

• Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
  Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG.
  Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3. Erratum in: Circulation.2008 Apr 15;117(15) e314.

  PMID: 18316486 Free PMC Article

• The tyrosine phosphatase Shp2 (PTPN11) in cancer.
  Chan G, Kalaitzidis D, Neel BG.
  Cancer Metastasis Rev. 2008 Jun;27(2):179-92. doi: 10.1007/s10555-008-9126-y. Review.

  PMID: 18286234

• Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
  Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB.
  J Biol Chem. 2008 May 23;283(21):14230-41. doi: 10.1074/jbc.M800061200. Epub 2008 Feb 14.

  PMID: 18281274 Free PMC Article

• SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
  Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG.
  Genes Chromosomes Cancer. 2008 Mar;47(3):253-9.

  PMID: 18064648

• Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
  Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG.
  Mol Cell Biol. 2007 Nov;27(21):7727-34. Epub 2007 Aug 27.

  PMID: 17724080 Free PMC Article

• B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
  Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, Thomas ML, Neel BG, Rajewsky K.
  Immunity. 2007 Jul;27(1):35-48. Epub 2007 Jun 28.

  PMID: 17600736 Free Article

• Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
  Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.
  J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.

  PMID: 17545163 Free Article

• Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.
  Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD.
  Neuron. 2007 Apr 19;54(2):245-62.

  PMID: 17442246 Free PMC Article

• Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
  Bentires-Alj M, Neel BG.
  Cancer Res. 2007 Mar 15;67(6):2420-4. Epub 2007 Mar 8.

  PMID: 17347513 Free Article

• Nonreceptor protein-tyrosine phosphatases in immune cell signaling.
  Pao LI, Badour K, Siminovitch KA, Neel BG.
  Annu Rev Immunol. 2007;25:473-523. Review.

  PMID: 17291189

• FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
  Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, Ivashkiv LB.
  Immunity. 2007 Jan;26(1):67-78.

  PMID: 17239631 Free Article

• The role of Shp2 (PTPN11) in cancer.
  Mohi MG, Neel BG.
  Curr Opin Genet Dev. 2007 Feb;17(1):23-30. Epub 2007 Jan 16. Review.

  PMID: 17227708

• Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer.
  Masiello D, Mohi MG, McKnight NC, Smith B, Neel BG, Balk SP, Bubley GJ.
  Cancer Biol Ther. 2007 Feb;6(2):195-201. Epub 2007 Feb 7.

  PMID: 17218776

• Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
  Yudushkin IA, Schleifenbaum A, Kinkhabwala A, Neel BG, Schultz C, Bastiaens PI.
  Science. 2007 Jan 5;315(5808):115-9.

  PMID: 17204654 Free Article

• Regulation of protein tyrosine phosphatase 1B by sumoylation.
  Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F 3rd, Shuai K, Ng T, Neel BG, Chernoff J.
  Nat Cell Biol. 2007 Jan;9(1):80-5. Epub 2006 Dec 10.

  PMID: 17159996

• Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
  Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS.
  Nat Genet. 2007 Jan;39(1):70-4. Epub 2006 Dec 3.

  PMID: 17143285

• SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.
  Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS.
  Immunity. 2006 Nov;25(5):769-81. Epub 2006 Nov 2.

  PMID: 17081782 Free Article

• SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth.
  Fornaro M, Burch PM, Yang W, Zhang L, Hamilton CE, Kim JH, Neel BG, Bennett AM.
  J Cell Biol. 2006 Oct 9;175(1):87-97. Epub 2006 Oct 2.

  PMID: 17015617 Free PMC Article

• ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
  Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ.
  Blood. 2007 Feb 1;109(3):1018-25. Epub 2006 Sep 26.

  PMID: 17003372 Free PMC Article

• The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
  Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H.
  J Biol Chem. 2006 Sep 29;281(39):28615-26. Epub 2006 Jul 27.

  PMID: 16873377 Free Article

• Neuronal PTP1B regulates body weight, adiposity and leptin action.
  Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.
  Nat Med. 2006 Aug;12(8):917-24. Epub 2006 Jul 16. Erratum in: Nat Med. 2010 Feb;16(2):237.

  PMID: 16845389

• Stops along the RAS pathway in human genetic disease.
  Bentires-Alj M, Kontaridis MI, Neel BG.
  Nat Med. 2006 Mar;12(3):283-5. No abstract available.

  PMID: 16520774

• An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.
  Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG.
  Dev Cell. 2006 Mar;10(3):317-27.

  PMID: 16516835 Free Article

• Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
  Yu M, Lowell CA, Neel BG, Gu H.
  J Immunol. 2006 Feb 15;176(4):2421-9.

  PMID: 16456001 Free Article

• PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.
  Kontaridis MI, Swanson KD, David FS, Barford D, Neel BG.
  J Biol Chem. 2006 Mar 10;281(10):6785-92. Epub 2005 Dec 23.

  PMID: 16377799 Free Article

• A role for the scaffolding adapter GAB2 in breast cancer.
  Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H.
  Nat Med. 2006 Jan;12(1):114-21. Epub 2005 Dec 20.

  PMID: 16369543

• A nomenclature for signal regulatory protein family members.
  van den Berg TK, van Beek EM, Bühring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN.
  J Immunol. 2005 Dec 15;175(12):7788-9. No abstract available.

  PMID: 16339511 Free Article

• Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
  Zhang Z, Lin SY, Neel BG, Haimovich B.
  J Biol Chem. 2006 Jan 20;281(3):1746-54. Epub 2005 Nov 15.

  PMID: 16291744 Free Article

• Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
  Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A.
  Mol Cell Biol. 2005 Sep;25(18):8052-63.

  PMID: 16135797 Free PMC Article

• Phosphatidylinositol 3-kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
  Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T.
  Mol Cell Biol. 2005 Sep;25(18):8001-8.

  PMID: 16135792 Free PMC Article

• PTP-1B is an essential positive regulator of platelet integrin signaling.
  Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ.
  J Cell Biol. 2005 Aug 29;170(5):837-45. Epub 2005 Aug 22.

  PMID: 16115959 Free PMC Article

• Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
  Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O’Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC.
  Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10238-43. Epub 2005 Jul 8.

  PMID: 16006513 Free PMC Article

• Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
  Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, Ivashkiv LB.
  Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10267-72. Epub 2005 Jul 6.

  PMID: 16000408 Free PMC Article

• Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
  Keilhack H, David FS, McGregor M, Cantley LC, Neel BG.
  J Biol Chem. 2005 Sep 2;280(35):30984-93. Epub 2005 Jun 29.

  PMID: 15987685 Free Article

• The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.
  Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG.
  Mol Cell. 2005 Jun 10;18(6):637-50.

  PMID: 15949439 Free Article

• Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.
  Haider UG, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM.
  Mol Pharmacol. 2005 Jul;68(1):41-8. Epub 2005 Apr 22.

  PMID: 15849355 Free Article

• Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.
  Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG.
  Cancer Cell. 2005 Feb;7(2):179-91.

  PMID: 15710330 Free Article

• Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
  Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG.
  J Biol Chem. 2005 Apr 15;280(15):15038-46. Epub 2005 Feb 7.

  PMID: 15699041 Free Article

• Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.
  Rusanescu G, Yang W, Bai A, Neel BG, Feig LA.
  EMBO J. 2005 Jan 26;24(2):305-14. Epub 2005 Jan 13.

  PMID: 15650750 Free PMC Article

• Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
  Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T.
  Mol Cell Biol. 2005 Jan;25(2):819-29.

  PMID: 15632081 Free PMC Article

• Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
  Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, Neel BG.
  Cancer Res. 2004 Dec 15;64(24):8816-20.

  PMID: 15604238 Free Article

• CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
  Sathish JG, Walters J, Luo JC, Johnson KG, Leroy FG, Brennan P, Kim KP, Gygi SP, Neel BG, Matthews RJ.
  J Biol Chem. 2004 Nov 12;279(46):47783-91. Epub 2004 Sep 10.

  PMID: 15364920 Free Article

• Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
  Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG.
  Nat Med. 2004 Aug;10(8):849-57. Epub 2004 Jul 25.

  PMID: 15273746

• CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.
  Chen J, McLean PA, Neel BG, Okunade G, Shull GE, Wortis HH.
  Nat Immunol. 2004 Jun;5(6):651-7. Epub 2004 May 9.

  PMID: 15133509

• Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.
  Shi ZD, Wei CQ, Lee K, Liu H, Zhang M, Araki T, Roberts LR, Worthy KM, Fisher RJ, Neel BG, Kelley JA, Yang D, Burke TR Jr.
  J Med Chem. 2004 Apr 8;47(8):2166-9.

  PMID: 15056012

• Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
  Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB.
  J Biol Chem. 2004 Jun 4;279(23):24844-51. Epub 2004 Mar 18.

  PMID: 15031294 Free Article

• Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
  Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG.
  Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3130-5. Epub 2004 Feb 19.

  PMID: 14976243 Free PMC Article

• Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
  Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG.
  Mol Cell. 2004 Feb 13;13(3):341-55.

  PMID: 14967142 Free Article

• Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
  Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Ostman A, Hellberg C.
  Mol Cell Biol. 2004 Mar;24(5):2190-201.

  PMID: 14966296 Free PMC Article

• Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
  Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF.
  Diabetes. 2004 Jan;53(1):61-6.

  PMID: 14693698 Free Article

• SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.
  Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR.
  J Cell Biol. 2003 Dec 8;163(5):999-1010.

  PMID: 14662744 Free PMC Article

• Signal transduction: an eye on organ development.
  Epstein JA, Neel BG.
  Nature. 2003 Nov 20;426(6964):238-9. No abstract available.

  PMID: 14628032

• Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
  Araki T, Nawa H, Neel BG.
  J Biol Chem. 2003 Oct 24;278(43):41677-84. Epub 2003 Aug 14.

  PMID: 12923167 Free Article

• The ‘Shp’ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.
  Neel BG, Gu H, Pao L.
  Trends Biochem Sci. 2003 Jun;28(6):284-93. Review.

  PMID: 12826400

• Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG.
  J Cell Biol. 2003 Jun 23;161(6):1151-61.

  PMID: 12821647 Free PMC Article

• The “Gab” in signal transduction.
  Gu H, Neel BG.
  Trends Cell Biol. 2003 Mar;13(3):122-30. Review.

  PMID: 12628344

• STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
  Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr.
  Nature. 2003 Feb 20;421(6925):856-9.

  PMID: 12594516

• Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways.
  Habib AA, Chun SJ, Neel BG, Vartanian T.
  Mol Cancer Res. 2003 Jan;1(3):219-33.

  PMID: 12556561 Free Article

• Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.
  Haj FG, Markova B, Klaman LD, Bohmer FD, Neel BG.
  J Biol Chem. 2003 Jan 10;278(2):739-44. Epub 2002 Nov 6.

  PMID: 12424235 Free Article

• SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
  Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.
  J Biol Chem. 2003 Jan 3;278(1):661-71. Epub 2002 Oct 27.

  PMID: 12403768 Free Article

• Direct identification of PTEN phosphorylation sites.
  Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG.
  FEBS Lett. 2002 Sep 25;528(1-3):145-53.

  PMID: 12297295 Free Article

• The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer.
  Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, Head DR, Henshall SM, Neel BG, Sutherland RL.
  Oncogene. 2002 Aug 1;21(33):5175-81.

  PMID: 12140767 Free Article

• Critical role for Gab2 in transformation by BCR/ABL.
  Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, Gu H, Griffin JD, Neel BG.
  Cancer Cell. 2002 Jun;1(5):479-92.

  PMID: 12124177 Free Article

• Mathematical models of protein kinase signal transduction.
  Heinrich R, Neel BG, Rapoport TA.
  Mol Cell. 2002 May;9(5):957-70.

  PMID: 12049733 Free Article

• Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2.
  Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG.
  Mol Cell Biol. 2002 Jun;22(12):4062-72.

  PMID: 12024020 Free PMC Article

• Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling.
  Jin L, McLean PA, Neel BG, Wortis HH.
  J Exp Med. 2002 May 6;195(9):1199-205.

  PMID: 11994425 Free PMC Article

• PTP1B regulates leptin signal transduction in vivo.
  Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG.
  Dev Cell. 2002 Apr;2(4):489-95.

  PMID: 11970898 Free Article

• Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum.
  Haj FG, Verveer PJ, Squire A, Neel BG, Bastiaens PI.
  Science. 2002 Mar 1;295(5560):1708-11.

  PMID: 11872838 Free Article

• Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.
  Bruecher-Encke B, Griffin JD, Neel BG, Lorenz U.
  Leukemia. 2001 Sep;15(9):1424-32.

  PMID: 11516103

• Essential role for Gab2 in the allergic response.
  Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Nature. 2001 Jul 12;412(6843):186-90.

  PMID: 11449275

• Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
  Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG.
  Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5187-92. Epub 2001 Apr 17.

  PMID: 11309481 Free PMC Article

• A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.
  Barber DL, Beattie BK, Mason JM, Nguyen MH, Yoakim M, Neel BG, D’Andrea AD, Frank DA.
  Blood. 2001 Apr 15;97(8):2230-7.

  PMID: 11290583 Free Article

• Combinatorial control of the specificity of protein tyrosine phosphatases.
  Tonks NK, Neel BG.
  Curr Opin Cell Biol. 2001 Apr;13(2):182-95. Review.

  PMID: 11248552

• Divergent roles of SHP-2 in ERK activation by leptin receptors.
  Bjørbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG Jr, Flier JS.
  J Biol Chem. 2001 Feb 16;276(7):4747-55. Epub 2000 Nov 20.

  PMID: 11085989 Free Article

• Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling.
  Pratt JC, Igras VE, Maeda H, Baksh S, Gelfand EW, Burakoff SJ, Neel BG, Gu H.
  J Immunol. 2000 Oct 15;165(8):4158-63.

  PMID: 11035047 Free Article

• Introduction: phosphatases in the immune system
  Neel BG.
  Semin Immunol. 2000 Aug;12(4):347-8. No abstract available.

  PMID: 10995581

• Dedication
  Neel BG.
  Semin Immunol. 2000 Aug;12(4):345-6. No abstract available.

  PMID: 10995580

• New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.
  Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG.
  Mol Cell Biol. 2000 Oct;20(19):7109-20.

  PMID: 10982827 Free PMC Article

• Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
  Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB.
  Mol Cell Biol. 2000 Aug;20(15):5479-89.

  PMID: 10891488 Free PMC Article

• The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
  Gadina M, Sudarshan C, Visconti R, Zhou YJ, Gu H, Neel BG, O’Shea JJ.
  J Biol Chem. 2000 Sep 1;275(35):26959-66.

  PMID: 10849428 Free Article

• Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
  Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB.
  J Biol Chem. 2000 Jun 16;275(24):18318-26.

  PMID: 10751417 Free Article

• Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
  Chen B, Bronson RT, Klaman LD, Hampton TG, Wang JF, Green PJ, Magnuson T, Douglas PS, Morgan JP, Neel BG.
  Nat Genet. 2000 Mar;24(3):296-9.

  PMID: 10700187

• A role for nuclear PTEN in neuronal differentiation.
  Lachyankar MB, Sultana N, Schonhoff CM, Mitra P, Poluha W, Lambert S, Quesenberry PJ, Litofsky NS, Recht LD, Nabi R, Miller SJ, Ohta S, Neel BG, Ross AH.
  J Neurosci. 2000 Feb 15;20(4):1404-13.

  PMID: 10662831 Free Article

• Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps.
  O’Reilly AM, Pluskey S, Shoelson SE, Neel BG.
  Mol Cell Biol. 2000 Jan;20(1):299-311.

  PMID: 10594032 Free PMC Article

• The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.
  Carter JD, Neel BG, Lorenz U.
  Int Immunol. 1999 Dec;11(12):1999-2014.

  PMID: 10590266

• SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages.
  Timms JF, Swanson KD, Marie-Cardine A, Raab M, Rudd CE, Schraven B, Neel BG.
  Curr Biol. 1999 Aug 26;9(16):927-30.

  PMID: 10469599 Free Article

• Identification of the erythropoietin receptor domain required for calcium channel activation.
  Miller BA, Barber DL, Bell LL, Beattie BK, Zhang MY, Neel BG, Yoakim M, Rothblum LI, Cheung JY.
  J Biol Chem. 1999 Jul 16;274(29):20465-72.

  PMID: 10400674 Free Article

• Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.
  Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM.
  Mol Cell Biol. 1999 Jul;19(7):4819-24.

  PMID: 10373531 Free PMC Article

• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
  Cantley LC, Neel BG.
  Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4240-5. Review.

  PMID: 10200246 Free PMC Article

• Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo.
  Bianchi C, Sellke FW, Del Vecchio RL, Tonks NK, Neel BG.
  Exp Cell Res. 1999 Apr 10;248(1):329-38.

  PMID: 10094839

• Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
  Oh ES, Gu H, Saxton TM, Timms JF, Hausdorff S, Frevert EU, Kahn BB, Pawson T, Neel BG, Thomas SM.
  Mol Cell Biol. 1999 Apr;19(4):3205-15.

  PMID: 10082587 Free PMC Article

• Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.
  Gu H, Pratt JC, Burakoff SJ, Neel BG.
  Mol Cell. 1998 Dec;2(6):729-40.

  PMID: 9885561 Free Article

• Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation.
  Moghal N, Neel BG.
  Mol Cell Biol. 1998 Nov;18(11):6666-78.

  PMID: 9774681 Free PMC Article

• The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.
  Wu Y, Nadler MJ, Brennan LA, Gish GD, Timms JF, Fusaki N, Jongstra-Bilen J, Tada N, Pawson T, Wither J, Neel BG, Hozumi N.
  Curr Biol. 1998 Sep 10;8(18):1009-17.

  PMID: 9740800 Free Article

• Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases.
  Siminovitch KA, Neel BG.
  Semin Immunol. 1998 Aug;10(4):329-47. Review.

  PMID: 9695189

• Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages.
  Timms JF, Carlberg K, Gu H, Chen H, Kamatkar S, Nadler MJ, Rohrschneider LR, Neel BG.
  Mol Cell Biol. 1998 Jul;18(7):3838-50.

  PMID: 9632768 Free PMC Article

• Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
  Barford D, Neel BG.
  Structure. 1998 Mar 15;6(3):249-54. Review.

  PMID: 9551546 Free Article

• Identification of a domain in the beta subunit of the type I interferon (IFN) receptor that exhibits a negative regulatory effect in the growth inhibitory action of type I IFNs.
  Platanias LC, Domanski P, Nadeau OW, Yi T, Uddin S, Fish E, Neel BG, Colamonici OR.
  J Biol Chem. 1998 Mar 6;273(10):5577-81.

  PMID: 9488684 Free Article

• Genetic analysis of protein tyrosine phosphatases.
  Van Vactor D, O’Reilly AM, Neel BG.
  Curr Opin Genet Dev. 1998 Feb;8(1):112-26. Review.

  PMID: 9529614

• Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction.
  O’Reilly AM, Neel BG.
  Mol Cell Biol. 1998 Jan;18(1):161-77.

  PMID: 9418864 Free PMC Article

• B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.
  Nadler MJ, McLean PA, Neel BG, Wortis HH.
  J Immunol. 1997 Nov 1;159(9):4233-43.

  PMID: 9379018

• Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activation.
  Nadler MJ, Chen B, Anderson JS, Wortis HH, Neel BG.
  J Biol Chem. 1997 Aug 8;272(32):20038-43.

  PMID: 9242674 Free Article

• Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.
  Gu H, Griffin JD, Neel BG.
  J Biol Chem. 1997 Jun 27;272(26):16421-30.

  PMID: 9195950 Free Article

• Role of phosphatases in lymphocyte activation.
  Neel BG.
  Curr Opin Immunol. 1997 Jun;9(3):405-20. Review.

  PMID: 9203419

• Protein tyrosine phosphatases in signal transduction.
  Neel BG, Tonks NK.
  Curr Opin Cell Biol. 1997 Apr;9(2):193-204.

  PMID: 9069265

• Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells.
  Shifrin VI, Davis RJ, Neel BG.
  J Biol Chem. 1997 Jan 31;272(5):2957-62.

  PMID: 9006942 Free Article

• From form to function: signaling by protein tyrosine phosphatases.
  Tonks NK, Neel BG.
  Cell. 1996 Nov 1;87(3):365-8. Review. No abstract available.

  PMID: 8898190 Free Article

• Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.
  Lorenz U, Ravichandran KS, Burakoff SJ, Neel BG.
  Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9624-9.

  PMID: 8790380 Free PMC Article

• Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.
  Lorenz U, Bergemann AD, Steinberg HN, Flanagan JG, Li X, Galli SJ, Neel BG.
  J Exp Med. 1996 Sep 1;184(3):1111-26.

  PMID: 9064328 Free PMC Article

• Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1.
  Chen HE, Chang S, Trub T, Neel BG.
  Mol Cell Biol. 1996 Jul;16(7):3685-97.

  PMID: 8668185 Free PMC Article

• Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression.
  Bennett AM, Hausdorff SF, O’Reilly AM, Freeman RM, Neel BG.
  Mol Cell Biol. 1996 Mar;16(3):1189-202.

  PMID: 8622663 Free PMC Article

• A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.
  Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM.
  Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):674-8.

  PMID: 8570614 Free PMC Article

• Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase.
  Itoh K, Tang TL, Neel BG, Sokol SY.
  Development. 1995 Dec;121(12):3979-88.

  PMID: 8575298 Free Article

• Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.
  David M, Chen HE, Goelz S, Larner AC, Neel BG.
  Mol Cell Biol. 1995 Dec;15(12):7050-8.

  PMID: 8524272 Free PMC Article

• Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer.
  Moghal N, Neel BG.
  Mol Cell Biol. 1995 Jul;15(7):3945-59.

  PMID: 7791800 Free PMC Article

• Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation.
  Hausdorff SF, Bennett AM, Neel BG, Birnbaum MJ.
  J Biol Chem. 1995 Jun 2;270(22):12965-8.

  PMID: 7768884 Free Article

• Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
  Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF.
  Cell. 1995 Mar 10;80(5):729-38.

  PMID: 7889566 Free Article

• The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development.
  Tang TL, Freeman RM Jr, O’Reilly AM, Neel BG, Sokol SY.
  Cell. 1995 Feb 10;80(3):473-83.

  PMID: 7859288 Free Article

• Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains.
  Pei D, Lorenz U, Klingmüller U, Neel BG, Walsh CT.
  Biochemistry. 1994 Dec 27;33(51):15483-93.

  PMID: 7528537

• Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
  Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG.
  Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7335-9.

  PMID: 8041791 Free PMC Article

• Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
  Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT.
  J Biol Chem. 1994 May 6;269(18):13614-22.

  PMID: 7513703 Free Article

• SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides.
  Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE.
  J Biol Chem. 1994 Apr 8;269(14):10467-74.

  PMID: 8144631 Free Article

• The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors.
  Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL.
  J Cell Sci. 1994 Apr;107 ( Pt 4):827-38.

  PMID: 8056839 Free Article

• Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
  Lorenz U, Ravichandran KS, Pei D, Walsh CT, Burakoff SJ, Neel BG.
  Mol Cell Biol. 1994 Mar;14(3):1824-34.

  PMID: 8114715 Free PMC Article

• Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA.
  Shifrin VI, Neel BG.
  J Biol Chem. 1993 Dec 5;268(34):25376-84.

  PMID: 8244970 Free Article

• Structure and function of SH2-domain containing tyrosine phosphatases.
  Neel BG.
  Semin Cell Biol. 1993 Dec;4(6):419-32. Review.

  PMID: 8305681

• Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.
  Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG.
  EMBO J. 1993 Dec;12(12):4843-56.

  PMID: 8223493 Free PMC Article

• Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2.
  Sugimoto S, Lechleider RJ, Shoelson SE, Neel BG, Walsh CT.
  J Biol Chem. 1993 Oct 25;268(30):22771-6.

  PMID: 8226787 Free Article

• Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
  Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE, Walsh CT, Neel BG.
  J Biol Chem. 1993 Oct 15;268(29):21478-81.

  PMID: 7691811 Free Article

• Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.
  Lechleider RJ, Freeman RM Jr, Neel BG.
  J Biol Chem. 1993 Jun 25;268(18):13434-8.

  PMID: 8514779 Free Article

• Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal.
  Frangioni JV, Neel BG.
  J Cell Sci. 1993 Jun;105 ( Pt 2):481-8.

  PMID: 8408279 Free Article

• Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.
  Frangioni JV, Neel BG.
  Anal Biochem. 1993 Apr;210(1):179-87.

  PMID: 8489015

• Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase.
  Pei D, Neel BG, Walsh CT.
  Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1092-6.

  PMID: 8430079 Free PMC Article

• Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
  Freeman RM Jr, Plutzky J, Neel BG.
  Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11239-43.

  PMID: 1280823 Free PMC Article

• Identification of an early-growth-response gene encoding a novel putative protein kinase.
  Simmons DL, Neel BG, Stevens R, Evett G, Erikson RL.
  Mol Cell Biol. 1992 Sep;12(9):4164-9.

  PMID: 1508211 Free PMC Article

• Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21.
  Shou C, Farnsworth CL, Neel BG, Feig LA.
  Nature. 1992 Jul 23;358(6384):351-4.

  PMID: 1379346

• Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
  Plutzky J, Neel BG, Rosenberg RD, Eddy RL, Byers MG, Jani-Sait S, Shows TB.
  Genomics. 1992 Jul;13(3):869-72.

  PMID: 1639416

• The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.
  Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG.
  Cell. 1992 Feb 7;68(3):545-60.

  PMID: 1739967

• Isolation of a src homology 2-containing tyrosine phosphatase.
  Plutzky J, Neel BG, Rosenberg RD.
  Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1123-7.

  PMID: 1736296 Free PMC Article

• High frequency of retinoic acid receptor beta abnormalities in human lung cancer.
  Gebert JF, Moghal N, Frangioni JV, Sugarbaker DJ, Neel BG.
  Oncogene. 1991 Oct;6(10):1859-68. Erratum in: Oncogene 1992 Apr;7(4):821.

  PMID: 1717924

• Cloning of a cDNA for a major human protein-tyrosine-phosphatase.
  Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG.
  Proc Natl Acad Sci U S A. 1990 Apr;87(7):2735-9.

  PMID: 2157211 Free PMC Article

• Localization of the cellular oncogenes ABL, SIS, and FES on human germ-line chromosomes.
  Jhanwar SC, Neel BG, Hayward WS, Chaganti RS.
  Cytogenet Cell Genet. 1984;38(1):73-5.

  PMID: 6323103

• Localization of c-ras oncogene family on human germ-line chromosomes.
  Jhanwar SC, Neel BG, Hayward WS, Chaganti RS.
  Proc Natl Acad Sci U S A. 1983 Aug;80(15):4794-7.

  PMID: 6308650 Free PMC Article

• The role of host c-onc genes in viral and non-viral neoplasia.
  Hayward WS, Neel BG, Shin CK, Jhanwar SC, Chaganti RS.
  Prog Clin Biol Res. 1983;119:119-32. No abstract available.

  PMID: 6867026

• Two human c-onc genes are located on the long arm of chromosome 8.
  Neel BG, Jhanwar SC, Chaganti RS, Hayward WS.
  Proc Natl Acad Sci U S A. 1982 Dec;79(24):7842-6.

  PMID: 6961456 Free PMC Article

• Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas.
  Neel BG, Gasic GP, Rogler CE, Skalka AM, Ju G, Hishinuma F, Papas T, Astrin SM, Hayward WS.
  J Virol. 1982 Oct;44(1):158-66.

  PMID: 6292482 Free PMC Article

• Isolation of 16L virus: a rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma.
  Neel BG, Wang LH, Mathey-Prevot B, Hanafusa T, Hanafusa H, Hayward WS.
  Proc Natl Acad Sci U S A. 1982 Aug;79(16):5088-92.

  PMID: 6289331 Free PMC Article

• Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.
  Hayward WS, Neel BG, Astrin SM.
  Nature. 1981 Apr 9;290(5806):475-80.

  PMID: 6261142

• Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion.
  Neel BG, Hayward WS, Robinson HL, Fang J, Astrin SM.
  Cell. 1981 Feb;23(2):323-34.

  PMID: 6258798

• Retroviral gene expression.
  Hayward WS, Neel BG.
  Curr Top Microbiol Immunol. 1981;91:217-76. Review. No abstract available.

  PMID: 7030642

• Avian lymphoid leukosis is correlated with the appearance of discrete new RNAs containing viral and cellular genetic information.
  Hayward WS, Neel BG, Fang J, Robinson HL, Astrin SM.
  Haematol Blood Transfus. 1981;26:439-44. No abstract available.

  PMID: 6274757

• Avian erythroblastosis virus produces two mRNA’s.
  Anderson SM, Hayward WS, Neel BG, Hanafusa H.
  J Virol. 1980 Dec;36(3):676-83.

  PMID: 6257919 Free PMC Article